Host cell invasion by apicomplexan pathogens such as the malaria parasite Plasmodium spp.and Toxoplasma gondii involves discharge of proteins from secretory organelles called micronemes and rhoptries.In Toxoplasma a protein complex comprising the microneme apical membrane antigen 1 (AMA1), two rhoptry neck proteins, and a protein called Ts4705, loc

BackgroundThe lockdown measures during the SARS-CoV-2 pandemic could have influenced drug consumption patterns of persons with drug use disorder, especially due to a reduced availability of drugs, an increased consumption of sedating substances as a coping strategy, or a shift to novel psychotropic substances (NPS) associated with an increased drug

Background Shipwrecks on the Baltic Sea seabed pose a serious threat to the marine environment.Fuel, ammunition and chemicals in their holds can enter the ecosystem at any time, causing an ecological disaster.It is known that oil spills from ship accidents can affect life and health of different species of animals, both immediately after catastroph

Abstract Background The advent of human-induced pluripotent stem cells holds great promise for producing ample individualized hepatocytes.Although previous efforts have succeeded in generating hepatocytes from human pluripotent stem cells in vitro by viral-based expression of transcription factors and/or addition of growth factors during the differ